Anti-CDC42 antibody (1-186) (STJ118103) STJ118103 上海玉博生物科技有限公司

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产品名称：Anti-CDC42 antibody (1-186) (STJ118103)
产品型号：STJ118103
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CDC42 antibody (1-186) (STJ118103)

产品描述

Host:	Rabbit
Applications:	IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CDC42 (1-186) is suitable for use in Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDC42
Gene ID:	998
Uniprot ID:	CDC42_HUMAN
Immunogen Region:	1-186
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human CDC42 (NP_001782.1).
Immunogen Sequence:	MQTIKCVVVGDGAVGKTCLL ISYTTNKFPSEYVPTVFDNY AVTVMIGGEPYTLGLFDTAG QEDYDRLRPLSYPQTDVFLV CFSVVSPSSFENVKEKWVPE ITHHCPKTPFLLVGTQIDLR DDPSTIEKLAKNKQKPITPE TAEKLARDLKAVKYVECSAL TQKGLKNVFDEAILAALEPP EPKKSR

Post Translational Modifications	(Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation.FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo. Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI. (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of CDC42 and leads to actin disassembly. (Microbial infection) Glucosylated at Thr-35 by C.difficile toxins TcdA and TcdB in the colonic epithelium. Monoglucosylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption and cell death, resulting in the loss of colonic epithelial barrier function. (Microbial infection) Glycosylated (O-GlcNAcylated) at Thr-35 by C.novyi toxin TcdA. O-GlcNAcylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption.
Function	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
Protein Name	Cell Division Control Protein 42 Homolog G25k Gtp-Binding Protein
Database Links	Reactome: R-HSA-114604 Reactome: R-HSA-182971 Reactome: R-HSA-2029482 Reactome: R-HSA-389359 Reactome: R-HSA-3928662 Reactome: R-HSA-418885 Reactome: R-HSA-428543 Reactome: R-HSA-4420097 Reactome: R-HSA-525793 Reactome: R-HSA-5625970 Reactome: R-HSA-5626467 Reactome: R-HSA-5627123 Reactome: R-HSA-5663213 Reactome: R-HSA-5663220 Reactome: R-HSA-5687128 Reactome: R-HSA-8950505 Reactome: R-HSA-8964616 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013406 Reactome: R-HSA-9013408 Reactome: R-HSA-9013409 Reactome: R-HSA-9013420 Reactome: R-HSA-9013423 Reactome: R-HSA-9013424 Reactome: R-HSA-9664422 Reactome: R-HSA-983231
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Spindle Midbody Cell Projection Dendrite Localizes To Spindle During Prometaphase Cells Moves To The Central Spindle As Cells Progressed Through Anaphase To Telophase Localizes At The End Of Cytokinesis In The Intercellular Bridge Formed Between Two Daughter Cells Its Localization Is Regulated By The Activities Of Guanine Nucleotide Exchange Factor Ect2 And Gtpase Activating Protein Racgap1 Colocalizes With Nek6 In The Centrosome In Its Active Gtp-Bound Form Localizes To The Leading Edge Membrane Of Migrating Dendritic Cells
Alternative Antibody Names	Anti-Cell Division Control Protein 42 Homolog antibody Anti-G25k Gtp-Binding Protein antibody Anti-CDC42 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CDC42 antibody (1-186) (STJ118103)