Anti-CDC42BPB antibody (1641-1690) (STJ94193) STJ94193 上海玉博生物科技有限公司

Anti-CDC42BPB antibody (1641-1690) (STJ94193)

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产品名称：Anti-CDC42BPB antibody (1641-1690) (STJ94193)
产品型号：STJ94193
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CDC42BPB antibody (1641-1690) (STJ94193)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Serine/threonine-protein kinase MRCK beta (1641-1690) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDC42BPB
Gene ID:	9578
Uniprot ID:	MRCKB_HUMAN
Immunogen Region:	1641-1690
Specificity:	MRCK Beta Polyclonal Antibody detects endogenous levels of MRCK Beta protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from human MRCKB. AA range:1641-1690

Tissue Specificity	Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.
Post Translational Modifications	Proteolytically cleaved by caspases upon apoptosis induction.
Function	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Protein Name	Serine/Threonine-Protein Kinase Mrck Beta Cdc42-Binding Protein Kinase Beta Cdc42bp-Beta Dmpk-Like Beta Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Beta Mrck Beta Myotonic Dystrophy Protein Kinase-Like Beta
Database Links	Reactome: R-HSA-9013148 Reactome: R-HSA-9013406 Reactome: R-HSA-9013409
Cellular Localisation	Cytoplasm Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Junction Cell Projection Lamellipodium Displays A Dispersed Punctate Distribution And Concentrates Along The Cell Periphery Especially At The Leading Edge And Cell-Cell Junction This Concentration Is Ph-Domain Dependent Detected At The Leading Edge Of Migrating Cells Localization At The Leading Edge Of Migrating Cells Requires Interaction With Catalytically Active Cdc42 Localizes In The Lamellipodium In A Fam89b/Lrap25-Dependent Manner
Alternative Antibody Names	Anti-Serine/Threonine-Protein Kinase Mrck Beta antibody Anti-Cdc42-Binding Protein Kinase Beta antibody Anti-Cdc42bp-Beta antibody Anti-Dmpk-Like Beta antibody Anti-Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Beta antibody Anti-Mrck Beta antibody Anti-Myotonic Dystrophy Protein Kinase-Like Beta antibody Anti-CDC42BPB antibody Anti-KIAA1124 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CDC42BPB antibody (1641-1690) (STJ94193)