Human PRAME (Preferentially Expressed Antigen In Melanoma) Sandwich ELISA Kit (STJE0011636) STJE0011636 上海玉博生物科技有限公司

Human PRAME (Preferentially Expressed Antigen In Melanoma) Sandwich ELISA Kit (STJE0011636)

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产品名称：Human PRAME (Preferentially Expressed Antigen In Melanoma) Sandwich ELISA Kit (STJE0011636)
产品型号：STJE0011636
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human PRAME (Preferentially Expressed Antigen In Melanoma) Sandwich ELISA Kit (STJE0011636)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.105ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This PRAME Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	PRAME
Gene ID:	23532
Uniprot ID:	PRAME_HUMAN
Sample Type:	tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Expressed in testis. Detected in samples of kidney, brain and skin.
Post Translational Modifications
Function	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Protein Name	Melanoma Antigen Preferentially Expressed In Tumors Opa-Interacting Protein 4 Oip-4 Preferentially Expressed Antigen Of Melanoma
Database Links
Cellular Localisation	Nucleus Chromosome Cytoplasm Golgi Apparatus Cell Membrane Associates With Chromatin Specifically Enriched At Transcriptionally Active Promoters That Are Also Bound By Nuclear Transcription Factor Y (Composed Of Nfya Nfyb And Nfyc) And At Enhancers Recruited To The Golgi Apparatus In Response To Interferon Gamma (Ifng) Treatment
Alternative ELISA Names	Melanoma Antigen Preferentially Expressed In Tumors ELISA kit Opa-Interacting Protein 4 ELISA kit Oip-4 ELISA kit Preferentially Expressed Antigen Of Melanoma ELISA kit PRAME ELISA kit MAPE ELISA kit OIP4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human PRAME (Preferentially Expressed Antigen In Melanoma) Sandwich ELISA Kit (STJE0011636)