Anti-CDK12 antibody (50-130 aa) (STJ191676) STJ191676 上海玉博生物科技有限公司

Anti-CDK12 antibody (50-130 aa) (STJ191676)

简单介绍

Anti-CDK12 antibody (50-130 aa) (STJ191676)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cyclin-dependent kinase 12 (50-130 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDK12
Gene ID:	51755
Uniprot ID:	CDK12_HUMAN
Immunogen Region:	50-130 aa
Specificity:	CDK12 Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from the human protein at the amino acid range 50-130

Post Translational Modifications	Phosphorylation at Thr-893 increases kinase activity.
Function	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Protein Name	Cyclin-Dependent Kinase 12 Cdc2-Related Kinase - Arginine/Serine-Rich Crkrs Cell Division Cycle 2-Related Protein Kinase 7 Cdc2-Related Protein Kinase 7 Cell Division Protein Kinase 12 Hcdk12
Database Links	Reactome: R-HSA-6796648
Cellular Localisation	Nucleus Nucleus Speckle Colocalized With Nuclear Speckles Throughout Interphase
Alternative Antibody Names	Anti-Cyclin-Dependent Kinase 12 antibody Anti-Cdc2-Related Kinase - Arginine/Serine-Rich antibody Anti-Crkrs antibody Anti-Cell Division Cycle 2-Related Protein Kinase 7 antibody Anti-Cdc2-Related Protein Kinase 7 antibody Anti-Cell Division Protein Kinase 12 antibody Anti-Hcdk12 antibody Anti-CDK12 antibody Anti-CRK7 antibody Anti-CRKRS antibody Anti-KIAA0904 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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