Anti-CDK4 antibody (1-50 aa) (STJ96563) STJ96563 上海玉博生物科技有限公司

Anti-CDK4 antibody (1-50 aa) (STJ96563)

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产品名称：Anti-CDK4 antibody (1-50 aa) (STJ96563)
产品型号：STJ96563
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CDK4 antibody (1-50 aa) (STJ96563)

产品描述

Host:	Rabbit
Applications:	IF/WB/IHC/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cyclin-dependent kinase 4 (1-50 aa) is suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IF 1:50-200 WB 1:500-1:2000 IHC-P 1:100-300 ELISA 1:20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDK4
Gene ID:	1019
Uniprot ID:	CDK4_HUMAN
Immunogen Region:	1-50 aa
Specificity:	Cdk4 Polyclonal Antibody detects endogenous levels of Cdk4 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the N-terminal region of human CDK4 at the amino acid range 1-50

Function	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Protein Name	Cyclin-Dependent Kinase 4 Cell Division Protein Kinase 4 Psk-J3
Database Links	Reactome: R-HSA-187577 Reactome: R-HSA-2559580 Reactome: R-HSA-2559582 Reactome: R-HSA-2559585 Reactome: R-HSA-3214858 Reactome: R-HSA-381340 Reactome: R-HSA-69231 Reactome: R-HSA-75815 Reactome: R-HSA-8849470 Reactome: R-HSA-8878166 Reactome: R-HSA-912446 Reactome: R-HSA-9616222 Reactome: R-HSA-9630791 Reactome: R-HSA-9630794 Reactome: R-HSA-9632697 Reactome: R-HSA-9632700 Reactome: R-HSA-9661069 Reactome: R-HSA-9754119
Cellular Localisation	Cytoplasm Nucleus Nucleus Membrane Cytoplasmic When Non-Complexed Forms A Cyclin D-Cdk4 Complex In The Cytoplasm As Cells Progress Through G(1) Phase The Complex Accumulates On The Nuclear Membrane And Enters The Nucleus On Transition From G(1) To S Phase Also Present In Nucleoli And Heterochromatin Lumps Colocalizes With Rb1 After Release Into The Nucleus
Alternative Antibody Names	Anti-Cyclin-Dependent Kinase 4 antibody Anti-Cell Division Protein Kinase 4 antibody Anti-Psk-J3 antibody Anti-CDK4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CDK4 antibody (1-50 aa) (STJ96563)