Anti-CDK4 antibody (200-303) (STJ11104280) STJ11104280 上海玉博生物科技有限公司

Anti-CDK4 antibody (200-303) (STJ11104280)

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产品名称：Anti-CDK4 antibody (200-303) (STJ11104280)
产品型号：STJ11104280
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CDK4 antibody (200-303) (STJ11104280)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IP/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cyclin-Dependent Kinase 4 (200-303) is suitable for use in Western Blot, Immunohistochemistry, Immunoprecipitation and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:100 IP 0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDK4
Gene ID:	1019
Uniprot ID:	CDK4_HUMAN
Immunogen Region:	200-303
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200-303 of human CDK4 (NP_000066.1).
Immunogen Sequence:	VGCIFAEMFRRKPLFCGNSE ADQLGKIFDLIGLPPEDDWP RDVSLPRGAFPPRGPRPVQS VVPEMEESGAQLLLEMLTFN PHKRISAFRALQHSYLHKDE GNPE

Post Translational Modifications	Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
Function	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Protein Name	Cyclin-Dependent Kinase 4 Cell Division Protein Kinase 4 Psk-J3
Database Links	Reactome: R-HSA-187577 Reactome: R-HSA-2559580 Reactome: R-HSA-2559582 Reactome: R-HSA-2559585 Reactome: R-HSA-3214858 Reactome: R-HSA-381340 Reactome: R-HSA-69231 Reactome: R-HSA-75815 Reactome: R-HSA-8849470 Reactome: R-HSA-8878166 Reactome: R-HSA-912446 Reactome: R-HSA-9616222 Reactome: R-HSA-9630791 Reactome: R-HSA-9630794 Reactome: R-HSA-9632697 Reactome: R-HSA-9632700 Reactome: R-HSA-9661069 Reactome: R-HSA-9754119
Cellular Localisation	Cytoplasm Nucleus Nucleus Membrane Cytoplasmic When Non-Complexed Forms A Cyclin D-Cdk4 Complex In The Cytoplasm As Cells Progress Through G(1) Phase The Complex Accumulates On The Nuclear Membrane And Enters The Nucleus On Transition From G(1) To S Phase Also Present In Nucleoli And Heterochromatin Lumps Colocalizes With Rb1 After Release Into The Nucleus
Alternative Antibody Names	Anti-Cyclin-Dependent Kinase 4 antibody Anti-Cell Division Protein Kinase 4 antibody Anti-Psk-J3 antibody Anti-CDK4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CDK4 antibody (200-303) (STJ11104280)