Human RANTES (Regulated On Activation In Normal T-Cell Expressed And Secreted) Sandwich ELISA Kit (STJE0007211) STJE0007211 上海玉博生物科技有限公司

Human RANTES (Regulated On Activation In Normal T-Cell Expressed And Secreted) Sandwich ELISA Kit (STJE0007211)

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产品名称：Human RANTES (Regulated On Activation In Normal T-Cell Expressed And Secreted) Sandwich ELISA Kit (STJE0007211)
产品型号：STJE0007211
产品展商：ST john's laboratory
产品文档：无相关文档

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Human RANTES (Regulated On Activation In Normal T-Cell Expressed And Secreted) Sandwich ELISA Kit (STJE0007211)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.073ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This RANTES Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	CCL5
Gene ID:	6352
Uniprot ID:	CCL5_HUMAN
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
Post Translational Modifications	N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG. The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Protein Name	C-C Motif Chemokine 5 Eocp Eosinophil Chemotactic Cytokine Sis-Delta Small-Inducible Cytokine A5 T Cell-Specific Protein P228 Tcp228 T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783
Cellular Localisation	Secreted
Alternative ELISA Names	C-C Motif Chemokine 5 ELISA kit Eocp ELISA kit Eosinophil Chemotactic Cytokine ELISA kit Sis-Delta ELISA kit Small-Inducible Cytokine A5 ELISA kit T Cell-Specific Protein P228 ELISA kit Tcp228 ELISA kit T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68 ELISA kit CCL5 ELISA kit D17S136E ELISA kit SCYA5 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human RANTES (Regulated On Activation In Normal T-Cell Expressed And Secreted) Sandwich ELISA Kit (STJE0007211)