Anti-CDX2 antibody (14-313) (STJ23086) STJ23086 上海玉博生物科技有限公司

Anti-CDX2 antibody (14-313) (STJ23086)

简单介绍

Anti-CDX2 antibody (14-313) (STJ23086)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CDX2 (14-313) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDX2
Gene ID:	1045
Uniprot ID:	CDX2_HUMAN
Immunogen Region:	14-313
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 14-313 of human CDX2 (NP_001256.3).
Immunogen Sequence:	YPSSVRHSGGLNLAPQNFVS PPQYPDYGGYHVAAAAAAAA NLDSAQSPGPSWPAAYGAPL REDWNGYAPGGAAAAANAVA HGLNGGSPAAAMGYSSPADY HPHHHPHHHPHHPAAAPSCA SGLLQTLNPGPPGPAATAAA EQLSPGGQRRNL

Tissue Specificity	Detected in small intestine, colon and pancreas.
Post Translational Modifications	Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
Function	Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Protein Name	Homeobox Protein Cdx-2 Cdx-3 Caudal-Type Homeobox Protein 2
Database Links	Reactome: R-HSA-381771
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Homeobox Protein Cdx-2 antibody Anti-Cdx-3 antibody Anti-Caudal-Type Homeobox Protein 2 antibody Anti-CDX2 antibody Anti-CDX3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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