Anti-CENPE antibody (2542-2701) (STJ117458) STJ117458 上海玉博生物科技有限公司

Anti-CENPE antibody (2542-2701) (STJ117458)

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产品名称：Anti-CENPE antibody (2542-2701) (STJ117458)
产品型号：STJ117458
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CENPE antibody (2542-2701) (STJ117458)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CENPE (2542-2701) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:200-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CENPE
Gene ID:	1062
Uniprot ID:	CENPE_HUMAN
Immunogen Region:	2542-2701
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 2542-2701 of human CENPE (NP_001804.2).
Immunogen Sequence:	ALILKSEHIRLEKEISKLKQ QNEQLIKQKNELLSNNQHLS NEVKTWKERTLKREAHKQVT CENSPKSPKVTGTASKKKQI TPSQCKERNLQDPVPKESPK SCFFDSRSKSLPSPHPVRYF DNSSLGLCPEVQNAGAESVD SQPGPWHASSGKDVPECKTQ

Post Translational Modifications	The C-terminal inhibitory domain is phosphorylated. Phosphorylation relieves autoinhibition of the kinetochore motor. Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association to the kinetochore.
Function	Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules. The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated. Acts as a processive bi-directional tracker of dynamic microtubule tips.after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends. Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized. Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss.
Protein Name	Centromere-Associated Protein E Centromere Protein E Cenp-E Kinesin-7 Kinesin-Related Protein Cenpe
Database Links	Reactome: R-HSA-141444 Reactome: R-HSA-2132295 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-5663220 Reactome: R-HSA-6811434 Reactome: R-HSA-68877 Reactome: R-HSA-9648025 Reactome: R-HSA-983189
Cellular Localisation	Chromosome Centromere Kinetochore Cytoplasm Cytoskeleton Spindle Associates With Kinetochores During Congression (As Early As Prometaphase) Relocates To The Spindle Midzone At Anaphase And Is Quantitatively Discarded At The End Of The Cell Division Recruited To The Kinetochore In A Sept7 Cenpq And Trappc12-Dependent Manner Recruited To The Pericentromeric/Centromeric Regions Of The Chromosome In A Ctcf-Dependent Manner
Alternative Antibody Names	Anti-Centromere-Associated Protein E antibody Anti-Centromere Protein E antibody Anti-Cenp-E antibody Anti-Kinesin-7 antibody Anti-Kinesin-Related Protein Cenpe antibody Anti-CENPE antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CENPE antibody (2542-2701) (STJ117458)