Anti-CENPF antibody (1730-1890) (STJ11100576) STJ11100576 上海玉博生物科技有限公司

Anti-CENPF antibody (1730-1890) (STJ11100576)

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产品名称：Anti-CENPF antibody (1730-1890) (STJ11100576)
产品型号：STJ11100576
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CENPF antibody (1730-1890) (STJ11100576)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CENPF (1730-1890) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CENPF
Gene ID:	1063
Uniprot ID:	CENPF_HUMAN
Immunogen Region:	1730-1890
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1730-1890 of human CENPF (NP_057427.3).
Immunogen Sequence:	NYEPPGEDKTQGSSECISEL SFSGPNALVPMDFLGNQEDI HNLQLRVKETSNENLRLLHV IEDRDRKVESLLNEMKELDS KLHLQEVQLMTKIEACIELE KIVGELKKENSDLSEKLEYF SCDHQELLQRVETSEGLNSD LEMHADKSSREDIGDNVAKV N

Post Translational Modifications	Hyperphosphorylated during mitosis.
Function	Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.
Protein Name	Centromere Protein F Cenp-F Ah Antigen Kinetochore Protein Cenpf Mitosin
Database Links	Reactome: R-HSA-141444 Reactome: R-HSA-156711 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-5663220 Reactome: R-HSA-68877 Reactome: R-HSA-9648025
Cellular Localisation	Cytoplasm Perinuclear Region Nucleus Matrix Chromosome Centromere Kinetochore Cytoskeleton Spindle Relocalizes To The Kinetochore/Centromere (Coronal Surface Of The Outer Plate) And The Spindle During Mitosis Observed In Nucleus During Interphase But Not In The Nucleolus At Metaphase Becomes Localized To Areas Including Kinetochore And Mitotic Apparatus As Well As Cytoplasm By Telophase Is Concentrated Within The Intracellular Bridge At Either Side Of The Mid-Body
Alternative Antibody Names	Anti-Centromere Protein F antibody Anti-Cenp-F antibody Anti-Ah Antigen antibody Anti-Kinetochore Protein Cenpf antibody Anti-Mitosin antibody Anti-CENPF antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CENPF antibody (1730-1890) (STJ11100576)