Anti-CEP164 antibody (STJA0006757) STJA0006757 上海玉博生物科技有限公司

Anti-CEP164 antibody (STJA0006757)

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产品名称：Anti-CEP164 antibody (STJA0006757)
产品型号：STJA0006757
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CEP164 antibody (STJA0006757)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Centrosomal protein of 164 kDa is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CEP164
Gene ID:	22897
Uniprot ID:	CE164_HUMAN
Specificity:	This antibody detects endogenous levels of CEP164 at Human
Immunogen:	Synthesized peptide derived from human CEP164

Post Translational Modifications	Phosphorylation at Ser-186 is induced upon DNA-damage caused by treatment with IR irradiation, UV irradiation, hydroxyurea or amphidicolin. Also MDC1-mediated chromatin remodeling is critical for DNA damage-induced phosphorylation.
Function	Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Protein Name	Centrosomal Protein Of 164 Kda Cep164
Database Links	Reactome: R-HSA-2565942 Reactome: R-HSA-380259 Reactome: R-HSA-380270 Reactome: R-HSA-380284 Reactome: R-HSA-380320 Reactome: R-HSA-5620912 Reactome: R-HSA-8854518
Cellular Localisation	Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Centriole Nucleus Localizes Specifically To Very Distally Located Appendage Structures On The Mature Centriole From Which Initiate Pc Formation Persisted At Centrioles Throughout Mitosis Expressed In Chromatin-Enriched Nuclear Fraction Of Hela Cells In Response To Dna Damage It Translocates To Nuclear Foci That Contain The Dna Damage Response Proteins Kat5/Tip60 And Chek1
Alternative Antibody Names	Anti-Centrosomal Protein Of 164 Kda antibody Anti-Cep164 antibody Anti-CEP164 antibody Anti-KIAA1052 antibody Anti-NPHP15 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CEP164 antibody (STJA0006757)