Anti-CAPRIN1 antibody (Internal) (STJ73106) STJ73106-100 上海玉博生物科技有限公司

Anti-CAPRIN1 antibody (Internal) (STJ73106)

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产品名称：Anti-CAPRIN1 antibody (Internal) (STJ73106)
产品型号：STJ73106-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CAPRIN1 antibody (Internal) (STJ73106)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IHC
Reactivity:	Human/Rat/Dog/Pig
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-CAPRIN1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-5µg/ml ELISA-antibody detection limit dilution 1:16000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	CAPRIN1
Gene ID:	4076
Uniprot ID:	CAPR1_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_005889.3; NP_976240.1
Specificity:	This antibody is expected to recognize both reported isoforms (NP_005889.3; NP_976240.1).
Immunogen Sequence:	EQRPQKEPIDQ

Post Translational Modifications	Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS).
Function	mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. Binds directly and selectively to MYC and CCND2 mRNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Protein Name	Caprin-1 Cell Cycle-Associated Protein 1 Cytoplasmic Activation- And Proliferation-Associated Protein 1 Gpi-Anchored Membrane Protein 1 Gpi-Anchored Protein P137 Gpi-P137 P137gpi Membrane Component Chromosome 11 Surface Marker 1 Rna Granule Protein 105
Cellular Localisation	Cytoplasm Cytoplasmic Ribonucleoprotein Granule Cytosol Cell Projection Dendrite Lamellipodium Mediates Formation And Localizes To Cytoplasmic Ribonucleoprotein Membraneless Compartments Associated With Rna Granules At The Leading Edge Of Migrating Fibroblasts Colocalizes With Ddx3x
Alternative Antibody Names	Anti-Caprin-1 antibody Anti-Cell Cycle-Associated Protein 1 antibody Anti-Cytoplasmic Activation- And Proliferation-Associated Protein 1 antibody Anti-Gpi-Anchored Membrane Protein 1 antibody Anti-Gpi-Anchored Protein P137 antibody Anti-Gpi-P137 antibody Anti-P137gpi antibody Anti-Membrane Component Chromosome 11 Surface Marker 1 antibody Anti-Rna Granule Protein 105 antibody Anti-CAPRIN1 antibody Anti-GPIAP1 antibody Anti-GPIP137 antibody Anti-M11S1 antibody Anti-RNG105 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CAPRIN1 antibody (Internal) (STJ73106)