Human SCNN1a (Amiloride Sensitive Sodium Channel Subunit Alpha) Sandwich ELISA Kit (STJE0012040) STJE0012040 上海玉博生物科技有限公司

Human SCNN1a (Amiloride Sensitive Sodium Channel Subunit Alpha) Sandwich ELISA Kit (STJE0012040)

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产品名称：Human SCNN1a (Amiloride Sensitive Sodium Channel Subunit Alpha) Sandwich ELISA Kit (STJE0012040)
产品型号：STJE0012040
产品展商：ST john's laboratory
产品文档：无相关文档

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Human SCNN1a (Amiloride Sensitive Sodium Channel Subunit Alpha) Sandwich ELISA Kit (STJE0012040)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.067ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This SCNN1a Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	SCNN1A
Gene ID:	6337
Uniprot ID:	SCNNA_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. in skin, expressed in keratinocytes, melanocytes and Merkel cells of the epidermal sub-layers, stratum basale, stratum spinosum and stratum granulosum (at protein level). Expressed in the outer root sheath of the hair follicles (at protein level). Detected in both peripheral and central cells of the sebaceous gland (at protein level). Expressed by eccrine sweat glands (at protein level). In skin, also expressed by arrector pili muscle cells and intradermal adipocytes. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.
Post Translational Modifications	Ubiquitinated.this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. N-glycosylated.
Function	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Protein Name	Amiloride-Sensitive Sodium Channel Subunit Alpha Alpha-Nach Epithelial Na(+ Channel Subunit Alpha Alpha-Enac Enaca Nonvoltage-Gated Sodium Channel 1 Subunit Alpha Scnea
Database Links	Reactome: R-HSA-2672351 Reactome: R-HSA-9730628
Cellular Localisation	Apical Cell Membrane Multi-Pass Membrane Protein Cell Projection Cilium Cytoplasmic Granule Cytoplasm Cytoplasmic Vesicle Secretory Vesicle Acrosome Flagellum In The Oviduct And Bronchus Located On Cilia In Multi-Ciliated Cells In Endometrial Non-Ciliated Epithelial Cells Restricted To Apical Surfaces In Epidermis Located Nearly Uniformly In The Cytoplasm In A Granular Distribution In Sebaceous Glands Observed Only In The Cytoplasmic Space In Between The Lipid Vesicles In Eccrine Sweat Glands Mainly Located At The Apical Surface Of The Cells Facing The Lumen In Skin In Arrector Pili Muscle Cells And In Adipocytes Located In The Cytoplasm And Colocalized With Actin Fibers In Spermatogonia Spermatocytes And Round Spermatids Located In The Cytoplasm Prior To Spermiation Location Shifts From The Cytoplasm To The Spermatid Tail In Spermatozoa Localizes At The Acrosome And The Central Region Of The Sperm Flagellum
Alternative ELISA Names	Amiloride-Sensitive Sodium Channel Subunit Alpha ELISA kit Alpha-Nach ELISA kit Epithelial Na(+ Channel Subunit Alpha ELISA kit Alpha-Enac ELISA kit Enaca ELISA kit Nonvoltage-Gated Sodium Channel 1 Subunit Alpha ELISA kit Scnea ELISA kit SCNN1A ELISA kit SCNN1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SCNN1a (Amiloride Sensitive Sodium Channel Subunit Alpha) Sandwich ELISA Kit (STJE0012040)