Anti-CFH antibody (19-323) (STJ23105) STJ23105 上海玉博生物科技有限公司

Anti-CFH antibody (19-323) (STJ23105)

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产品名称：Anti-CFH antibody (19-323) (STJ23105)
产品型号：STJ23105
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CFH antibody (19-323) (STJ23105)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CFH (19-323) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CFH
Gene ID:	3075
Uniprot ID:	CFAH_HUMAN
Immunogen Region:	19-323
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 19-323 of human Complement factor H (NP_000177.2).
Immunogen Sequence:	EDCNELPPRRNTEILTGSWS DQTYPEGTQAIYKCRPGYRS LGNVIMVCRKGEWVALNPLR KCQKRPCGHPGDTPFGTFTL TGGNVFEYGVKAVYTCNEGY QLLGEINYRECDTDGWTNDI PICEVVKCLPVTAPENGKIV SSAMEPDREYHFGQAVRFVC NSGYKIEGDEEMHCSDDGFW SKEKPKCVEISCKSPDVING SPISQKIIYKENERFQYKCN MGYEYSERGDAVCTESGWR

Tissue Specificity	Expressed in the retinal pigment epithelium (at protein level). CFH is one of the most abundant complement components in blood where the liver is the major source of CFH protein in vivo. in addition, CFH is secreted by additional cell types including monocytes, fibroblasts, or endothelial cells.
Post Translational Modifications	Sulfated on tyrosine residues.
Function	Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination.
Protein Name	Complement Factor H H Factor 1
Database Links	Reactome: R-HSA-977606
Cellular Localisation	Secreted (Microbial Infection) In The Mosquito Midgut Localizes To P Falciparum (Nf54 Strain) Macrogamete And Young Zygote Cell Membranes
Alternative Antibody Names	Anti-Complement Factor H antibody Anti-H Factor 1 antibody Anti-CFH antibody Anti-HF antibody Anti-HF1 antibody Anti-HF2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CFH antibody (19-323) (STJ23105)