Anti-CFL1 antibody (120-166) (STJ500501) STJ500501-100 上海玉博生物科技有限公司

Anti-CFL1 antibody (120-166) (STJ500501)

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产品名称：Anti-CFL1 antibody (120-166) (STJ500501)
产品型号：STJ500501-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CFL1 antibody (120-166) (STJ500501)

产品描述

Host:	Rabbit
Applications:	CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CFL1 (120-166) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IHC: 1:50 ICC: 1:50 IF: 1:50
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CFL1
Gene ID:	1072
Uniprot ID:	COF1_HUMAN
Immunogen Region:	120-166
Immunogen:	Synthetic peptide taken within amino acid region 120-170 on human Cofilin protein.

Tissue Specificity	Widely distributed in various tissues.
Post Translational Modifications	Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells. Dephosphorylated by PDXP/chronophin.this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.
Function	Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the centralization of the mitotic spindle and symmetric division of zygotes. Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.
Protein Name	Cofilin-1 18 Kda Phosphoprotein P18 Cofilin - Non-Muscle Isoform
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-2029482 Reactome: R-HSA-3928662 Reactome: R-HSA-399954 Reactome: R-HSA-5627117 Reactome: R-HSA-8950505
Cellular Localisation	Nucleus Matrix Cytoplasm Cytoskeleton Cell Projection Ruffle Membrane Peripheral Membrane Protein Cytoplasmic Side Lamellipodium Membrane Lamellipodium Growth Cone Axon Colocalizes With The Actin Cytoskeleton In Membrane Ruffles And Lamellipodia Detected At The Cleavage Furrow And Contractile Ring During Cytokinesis Almost Completely In Nucleus In Cells Exposed To Heat Shock Or 10% Dimethyl Sulfoxide
Alternative Antibody Names	Anti-Cofilin-1 antibody Anti-18 Kda Phosphoprotein antibody Anti-P18 antibody Anti-Cofilin - Non-Muscle Isoform antibody Anti-CFL1 antibody Anti-CFL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CFL1 antibody (120-166) (STJ500501)