Anti-CFLAR antibody (90-240) (STJ23109) STJ23109 上海玉博生物科技有限公司

Anti-CFLAR antibody (90-240) (STJ23109)

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产品名称：Anti-CFLAR antibody (90-240) (STJ23109)
产品型号：STJ23109
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CFLAR antibody (90-240) (STJ23109)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-cFLIP (90-240) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CFLAR
Gene ID:	8837
Uniprot ID:	CFLAR_HUMAN
Immunogen Region:	90-240
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 90-240 of human cFLIP (NP_003870.4).
Immunogen Sequence:	VSDYRVLMAEIGEDLDKSDV SSLIFLMKDYMGRGKISKEK SFLDLVVELEKLNLVAPDQL DLLEKCLKNIHRIDLKTKIQ KYKQSVQGAGTSYRNVLQAA IQKSLKDPSNNFRLHNGRSK EQRLKEQLGAQQEPVKKSIQ ESEAFLPQSIP

Tissue Specificity	Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Post Translational Modifications	Proteolytically processed by CASP8 generating subunit p43 and p12.
Function	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Protein Name	Casp8 And Fadd-Like Apoptosis Regulator Caspase Homolog Cash Caspase-Eight-Related Protein Casper Caspase-Like Apoptosis Regulatory Protein Clarp Cellular Flice-Like Inhibitory Protein C-Flip Fadd-Like Antiapoptotic Molecule 1 Flame-1 Inhibitor Of Flice I-Flice Mach-Related Inducer Of Toxicity Mrit Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12
Database Links	Reactome: R-HSA-3371378 O15519-1 Reactome: R-HSA-5213460 Reactome: R-HSA-5218900 Reactome: R-HSA-5357905 O15519-1 Reactome: R-HSA-69416 O15519-2 Reactome: R-HSA-75158
Alternative Antibody Names	Anti-Casp8 And Fadd-Like Apoptosis Regulator antibody Anti-Caspase Homolog antibody Anti-Cash antibody Anti-Caspase-Eight-Related Protein antibody Anti-Casper antibody Anti-Caspase-Like Apoptosis Regulatory Protein antibody Anti-Clarp antibody Anti-Cellular Flice-Like Inhibitory Protein antibody Anti-C-Flip antibody Anti-Fadd-Like Antiapoptotic Molecule 1 antibody Anti-Flame-1 antibody Anti-Inhibitor Of Flice antibody Anti-I-Flice antibody Anti-Mach-Related Inducer Of Toxicity antibody Anti-Mrit antibody Anti-Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 antibody Anti-CFLAR antibody Anti-CASH antibody Anti-CASP8AP1 antibody Anti-CLARP antibody Anti-MRIT antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CFLAR antibody (90-240) (STJ23109)