Anti-CFTR antibody (700-840) (STJ110684) STJ110684 上海玉博生物科技有限公司

Anti-CFTR antibody (700-840) (STJ110684)

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产品名称：Anti-CFTR antibody (700-840) (STJ110684)
产品型号：STJ110684
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CFTR antibody (700-840) (STJ110684)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CFTR (700-840) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CFTR
Gene ID:	1080
Uniprot ID:	CFTR_HUMAN
Immunogen Region:	700-840
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 700-840 of human CFTR (NP_000483.3).
Immunogen Sequence:	SILNPINSIRKFSIVQKTPL QMNGIEEDSDEPLERRLSLV PDSEQGEAILPRISVISTGP TLQARRRQSVLNLMTHSVNQ GQNIHRKTTASTRKVSLAPQ ANLTELDIYSRRLSQETGLE ISEEINEEDLKECFFDDMES I

Tissue Specificity	Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level). Detected in pancreatic intercalated ducts in the exocrine tissue, on epithelial cells in intralobular striated ducts in sublingual salivary glands, on apical membranes of crypt cells throughout the small and large intestine, and on the reabsorptive duct in eccrine sweat glands. Detected on the equatorial segment of the sperm head (at protein level). Detected in nasal and bronchial superficial epithelium. Expressed by the central cells on the sebaceous glands, dermal adipocytes and, at lower levels, by epithelial cells.
Post Translational Modifications	N-glycosylated. Phosphorylated.cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK.this inhibits channel activity. Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2.
Function	Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-).selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G. Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Protein Name	Cystic Fibrosis Transmembrane Conductance Regulator Cftr Atp-Binding Cassette Sub-Family C Member 7 Channel Conductance-Controlling Atpase Camp-Dependent Chloride Channel
Database Links	Reactome: R-HSA-382556 Reactome: R-HSA-5627083 Reactome: R-HSA-5678895 Reactome: R-HSA-5689880 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-9013406 Reactome: R-HSA-9613829 Reactome: R-HSA-9615710 Reactome: R-HSA-9646399
Cellular Localisation	Apical Cell Membrane Multi-Pass Membrane Protein Early Endosome Membrane Cell Membrane Recycling Endosome Membrane Endoplasmic Reticulum Membrane Nucleus The Channel Is Internalized From The Cell Surface Into An Endosomal Recycling Compartment From Where It Is Recycled To The Cell Membrane In The Oviduct And Bronchus Detected On The Apical Side Of Epithelial Cells But Not Associated With Cilia In Sertoli Cells A Processed Product Is Detected In The Nucleus Er Stress Induces Gorasp2-Mediated Unconventional (Er/Golgi-Independent) Trafficking Of Core-Glycosylated Cftr To Cell Membrane
Alternative Antibody Names	Anti-Cystic Fibrosis Transmembrane Conductance Regulator antibody Anti-Cftr antibody Anti-Atp-Binding Cassette Sub-Family C Member 7 antibody Anti-Channel Conductance-Controlling Atpase antibody Anti-Camp-Dependent Chloride Channel antibody Anti-CFTR antibody Anti-ABCC7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CFTR antibody (700-840) (STJ110684)