Anti-CFTR antibody (711-760 aa) (STJ92253) STJ92253 上海玉博生物科技有限公司

Anti-CFTR antibody (711-760 aa) (STJ92253)

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产品名称：Anti-CFTR antibody (711-760 aa) (STJ92253)
产品型号：STJ92253
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CFTR antibody (711-760 aa) (STJ92253)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cystic fibrosis transmembrane conductance regulator (711-760 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CFTR
Gene ID:	1080
Uniprot ID:	CFTR_HUMAN
Immunogen Region:	711-760 aa
Specificity:	CFTR Polyclonal Antibody detects endogenous levels of CFTR protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human CFTR at the amino acid range 711-760

Post Translational Modifications	N-glycosylated. Phosphorylated.cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK.this inhibits channel activity. Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2.
Function	Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-).selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G. Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Protein Name	Cystic Fibrosis Transmembrane Conductance Regulator Cftr Atp-Binding Cassette Sub-Family C Member 7 Channel Conductance-Controlling Atpase Camp-Dependent Chloride Channel
Database Links	Reactome: R-HSA-382556 Reactome: R-HSA-5627083 Reactome: R-HSA-5678895 Reactome: R-HSA-5689880 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-9013406 Reactome: R-HSA-9613829 Reactome: R-HSA-9615710 Reactome: R-HSA-9646399
Cellular Localisation	Apical Cell Membrane Multi-Pass Membrane Protein Early Endosome Membrane Cell Membrane Recycling Endosome Membrane Endoplasmic Reticulum Membrane Nucleus The Channel Is Internalized From The Cell Surface Into An Endosomal Recycling Compartment From Where It Is Recycled To The Cell Membrane In The Oviduct And Bronchus Detected On The Apical Side Of Epithelial Cells But Not Associated With Cilia In Sertoli Cells A Processed Product Is Detected In The Nucleus Er Stress Induces Gorasp2-Mediated Unconventional (Er/Golgi-Independent) Trafficking Of Core-Glycosylated Cftr To Cell Membrane
Alternative Antibody Names	Anti-Cystic Fibrosis Transmembrane Conductance Regulator antibody Anti-Cftr antibody Anti-Atp-Binding Cassette Sub-Family C Member 7 antibody Anti-Channel Conductance-Controlling Atpase antibody Anti-Camp-Dependent Chloride Channel antibody Anti-CFTR antibody Anti-ABCC7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CFTR antibody (711-760 aa) (STJ92253)