Anti-CH25H antibody (171-270) (STJ11105307) STJ11105307 上海玉博生物科技有限公司

Anti-CH25H antibody (171-270) (STJ11105307)

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产品名称：Anti-CH25H antibody (171-270) (STJ11105307)
产品型号：STJ11105307
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CH25H antibody (171-270) (STJ11105307)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cholesterol 25-Hydroxylase (171-270) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CH25H
Gene ID:	9023
Uniprot ID:	CH25H_HUMAN
Immunogen Region:	171-270
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 171-270 of human Ch25h (NP_003947.1).
Immunogen Sequence:	TQYMSVWELFSLGFFDMMNV TLLGCHPLTTLTFHVVNIWL SVEDHSGYNFPWSTHRLVPF GWYGGVVHHDLHHSHFNCNF APYFTHWDKILGTLRTASVP

Post Translational Modifications	N-glycosylated.
Function	Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses, such as vesicular stomatitis virus (VSV) and SARS coronavirus-2 (SARS-CoV-2). Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts SARS-CoV-2 S protein-mediated fusion which inhibits virus replication. In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation. Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome.
Protein Name	Cholesterol 25-Hydroxylase Cholesterol 25-Monooxygenase H25oh
Database Links	Reactome: R-HSA-192105
Cellular Localisation	Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Cholesterol 25-Hydroxylase antibody Anti-Cholesterol 25-Monooxygenase antibody Anti-H25oh antibody Anti-CH25H antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CH25H antibody (171-270) (STJ11105307)