Anti-CHAC1 antibody (1-222) (STJ118037) STJ118037 上海玉博生物科技有限公司

Anti-CHAC1 antibody (1-222) (STJ118037)

简单介绍

Anti-CHAC1 antibody (1-222) (STJ118037)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CHAC1 (1-222) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHAC1
Gene ID:	79094
Uniprot ID:	CHAC1_HUMAN
Immunogen Region:	1-222
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human CHAC1 (NP_077016.3).
Immunogen Sequence:	MKQESAAPNTPPTSQSPTPS AQFPRNDGDPQALWIFGYGS LVWRPDFAYSDSRVGFVRGY SRRFWQGDTFHRGSDKMPGR VVTLLEDHEGCTWGVAYQVQ GEQVSKALKYLNVREAVLGG YDTKEVTFYPQDAPDQPLKA LAYVATPQNPGYLGPAPEEA IATQILACRGFSGHNLEYLL RLADFMQLCGPQAQDEHLAA IVDAVGTMLPCFCPTEQALA LV

Function	Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
Protein Name	Glutathione-Specific Gamma-Glutamylcyclotransferase 1 Gamma-Gcg 1 Blocks Notch Protein Botch Cation Transport Regulator-Like Protein 1
Database Links	Reactome: R-HSA-174403 Reactome: R-HSA-9648895
Cellular Localisation	Cytoplasm Cytosol Golgi Apparatus Trans-Golgi Network
Alternative Antibody Names	Anti-Glutathione-Specific Gamma-Glutamylcyclotransferase 1 antibody Anti-Gamma-Gcg 1 antibody Anti-Blocks Notch Protein antibody Anti-Botch antibody Anti-Cation Transport Regulator-Like Protein 1 antibody Anti-CHAC1 antibody Anti-BOTCH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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