Anti-CHCHD4 antibody (35-85 aa) (STJ193463) STJ193463 上海玉博生物科技有限公司

Anti-CHCHD4 antibody (35-85 aa) (STJ193463)

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产品名称：Anti-CHCHD4 antibody (35-85 aa) (STJ193463)
产品型号：STJ193463
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHCHD4 antibody (35-85 aa) (STJ193463)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Mitochondrial intermembrane space import and assembly protein 40 (35-85 aa) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHCHD4
Gene ID:	131474
Uniprot ID:	MIA40_HUMAN
Immunogen Region:	35-85 aa
Specificity:	This antibody detects endogenous levels of CHCHD4 at Human/Mouse/Rat
Immunogen:	Synthesized peptide derived from the human CHCHD4 at the amino acid range 35-85

Post Translational Modifications	Forms intrachain disulfide bridges, but exists in different redox states.
Function	Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes. Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake.
Protein Name	Mitochondrial Intermembrane Space Import And Assembly Protein 40 Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 4
Database Links	Reactome: R-HSA-1268020
Cellular Localisation	Mitochondrion Intermembrane Space
Alternative Antibody Names	Anti-Mitochondrial Intermembrane Space Import And Assembly Protein 40 antibody Anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 4 antibody Anti-CHCHD4 antibody Anti-MIA40 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHCHD4 antibody (35-85 aa) (STJ193463)