Anti-Casein Kinase 1, delta antibody (Internal) (STJ70916) STJ70916-100 上海玉博生物科技有限公司

Anti-Casein Kinase 1, delta antibody (Internal) (STJ70916)

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产品名称：Anti-Casein Kinase 1, delta antibody (Internal) (STJ70916)
产品型号：STJ70916-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Casein Kinase 1, delta antibody (Internal) (STJ70916)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IF
Reactivity:	Human/Mouse/Rat/Dog
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-Casein Kinase 1, delta (Internal) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.1-0.3µg/ml IF-Expression of the protein seen in the Nucleus of U251 cells. 10µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	CSNK1D
Gene ID:	1453
Uniprot ID:	KC1D_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_001884.2; NP_620693.1
Specificity:	This antibody is expected to recognise both reported isoforms (NP_001884.2 and NP_620693.1)
Immunogen Sequence:	DREERLRHSRNPATR

Post Translational Modifications	Autophosphorylated on serine and threonine residues.this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.
Function	Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.
Protein Name	Casein Kinase I Isoform Delta Cki-Delta Ckid Tau-Protein Kinase Csnk1d
Database Links	Reactome: R-HSA-204005 Reactome: R-HSA-2565942 Reactome: R-HSA-380259 Reactome: R-HSA-380270 Reactome: R-HSA-380284 Reactome: R-HSA-380320 Reactome: R-HSA-400253 Reactome: R-HSA-5620912 Reactome: R-HSA-6791226 Reactome: R-HSA-8854518
Cellular Localisation	Cytoplasm Nucleus Cytoskeleton Microtubule Organizing Center Centrosome Perinuclear Region Cell Membrane Spindle Golgi Apparatus Localized At Mitotic Spindle Microtubules And At The Centrosomes And Interphase In Interphase Cells Recruited To The Spindle Apparatus And The Centrosomes In Response To Dna-Damage Correct Subcellular Localization Requires Kinase Activity
Alternative Antibody Names	Anti-Casein Kinase I Isoform Delta antibody Anti-Cki-Delta antibody Anti-Ckid antibody Anti-Tau-Protein Kinase Csnk1d antibody Anti-CSNK1D antibody Anti-HCKID antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Casein Kinase 1, delta antibody (Internal) (STJ70916)