Human SESN2 (Sestrin 2) Sandwich ELISA Kit Ready-To-Use (STJE0018498) STJE0018498 上海玉博生物科技有限公司

Human SESN2 (Sestrin 2) Sandwich ELISA Kit Ready-To-Use (STJE0018498)

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产品名称：Human SESN2 (Sestrin 2) Sandwich ELISA Kit Ready-To-Use (STJE0018498)
产品型号：STJE0018498
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SESN2 (Sestrin 2) Sandwich ELISA Kit Ready-To-Use (STJE0018498)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.055ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This SESN2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	SESN2
Gene ID:	83667
Uniprot ID:	SESN2_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Widely expressed.
Post Translational Modifications	Phosphorylated by ULK1 at multiple sites. Ubiquitinated at Lys-175 by RNF167 via 'Lys-63'-linked polyubiquitination in response to leucine deprivation: ubiquitination promotes SESN2-interaction with the GATOR2 complex, leading to inhibit the TORC1 signaling pathway. Deubiquitinated at Lys-175 by STAMBPL1, promoting the TORC1 signaling pathway. Ubiquitinated by RNF186.ubiquitination mediates proteasomal degradation.
Function	Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
Protein Name	Sestrin-2 Hypoxia-Induced Gene
Database Links	Reactome: R-HSA-5628897 Reactome: R-HSA-9639288 Reactome: R-HSA-9755511
Cellular Localisation	Cytoplasm
Alternative ELISA Names	Sestrin-2 ELISA kit Hypoxia-Induced Gene ELISA kit SESN2 ELISA kit Hi95 ELISA kit SEST2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SESN2 (Sestrin 2) Sandwich ELISA Kit Ready-To-Use (STJE0018498)