Human SETD7 (SET Domain Containing Protein 7) Sandwich ELISA Kit Ready-To-Use (STJE0018502) STJE0018502 上海玉博生物科技有限公司

Human SETD7 (SET Domain Containing Protein 7) Sandwich ELISA Kit Ready-To-Use (STJE0018502)

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产品名称：Human SETD7 (SET Domain Containing Protein 7) Sandwich ELISA Kit Ready-To-Use (STJE0018502)
产品型号：STJE0018502
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SETD7 (SET Domain Containing Protein 7) Sandwich ELISA Kit Ready-To-Use (STJE0018502)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.054ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This SETD7 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	SETD7
Gene ID:	80854
Uniprot ID:	SETD7_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Widely expressed. Expressed in pancreatic islets.
Post Translational Modifications
Function	Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS.
Protein Name	Histone-Lysine N-Methyltransferase Setd7 Histone H3-K4 Methyltransferase Setd7 H3-K4-Hmtase Setd7 Lysine N-Methyltransferase 7 Set Domain-Containing Protein 7 Set7/9
Database Links	Reactome: R-HSA-3214841
Cellular Localisation	Nucleus Chromosome
Alternative ELISA Names	Histone-Lysine N-Methyltransferase Setd7 ELISA kit Histone H3-K4 Methyltransferase Setd7 ELISA kit H3-K4-Hmtase Setd7 ELISA kit Lysine N-Methyltransferase 7 ELISA kit Set Domain-Containing Protein 7 ELISA kit Set7/9 ELISA kit SETD7 ELISA kit KIAA1717 ELISA kit KMT7 ELISA kit SET7 ELISA kit SET9 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SETD7 (SET Domain Containing Protein 7) Sandwich ELISA Kit Ready-To-Use (STJE0018502)