Anti-CHD1L antibody (700-800) [S3MR] (STJ11102913) STJ11102913 上海玉博生物科技有限公司

Anti-CHD1L antibody (700-800) [S3MR] (STJ11102913)

简单介绍

Anti-CHD1L antibody (700-800) [S3MR] (STJ11102913)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-CHD1L (700-800) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S3MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHD1L
Gene ID:	9557
Uniprot ID:	CHD1L_HUMAN
Immunogen Region:	700-800
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 700-800 of human CHD1L (NP_004275.).
Immunogen Sequence:	GEESSAELDYQDPDATSLKY VSGDVTHPQAGAEDALIVHC VDDSGHWGRGGLFTALEKRS AEPRKIYELAGKMKDLSLGG VLLFPVDDKESRNKGQDLLA L

Tissue Specificity	Frequently overexpressed in hepatomacellular carcinomas.
Function	ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin.
Protein Name	Chromodomain-Helicase-Dna-Binding Protein 1-Like Amplified In Liver Cancer Protein 1
Database Links	Reactome: R-HSA-5696395 Reactome: R-HSA-5696400
Cellular Localisation	Nucleus Chromosome Localizes At Sites Of Dna Damage Recruited By Histones H2b And H3 Poly-Adp-Ribosylated On 'Ser-6' And 'Ser-10' Respectively (H2bs6adpr And H3s10adpr) By Parp1 Or Parp2
Alternative Antibody Names	Anti-Chromodomain-Helicase-Dna-Binding Protein 1-Like antibody Anti-Amplified In Liver Cancer Protein 1 antibody Anti-CHD1L antibody Anti-ALC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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