Anti-CHI3L1 antibody (22-383) (STJ116193) STJ116193 上海玉博生物科技有限公司

Anti-CHI3L1 antibody (22-383) (STJ116193)

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产品名称：Anti-CHI3L1 antibody (22-383) (STJ116193)
产品型号：STJ116193
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHI3L1 antibody (22-383) (STJ116193)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-YKL-40/CHI3L1 (22-383) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHI3L1
Gene ID:	1116
Uniprot ID:	CH3L1_HUMAN
Immunogen Region:	22-383
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-383 of YKL-40/CHI3L1 (NP_001267.2).
Immunogen Sequence:	YKLVCYYTSWSQYREGDGSC FPDALDRFLCTHIIYSFANI SNDHIDTWEWNDVTLYGMLN TLKNRNPNLKTLLSVGGWNF GSQRFSKIASNTQSRRTFIK SVPPFLRTHGFDGLDLAWLY PGRRDKQHFTTLIKEMKAEF IKEAQPGKKQLLLSAALSAG KVTIDSSYDIAKISQHLDFI SIMTYDFHGAWRGTTGHHSP LFRGQEDASPDRFSNTDYAV GYMLRLGAPASKLVMGIPT

Tissue Specificity	Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.
Post Translational Modifications	Glycosylated.
Function	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Protein Name	Chitinase-3-Like Protein 1 39 Kda Synovial Protein Cartilage Glycoprotein 39 Cgp-39 Gp-39 Hcgp-39 Ykl-40
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Secreted Extracellular Space Cytoplasm Perinuclear Region Endoplasmic Reticulum
Alternative Antibody Names	Anti-Chitinase-3-Like Protein 1 antibody Anti-39 Kda Synovial Protein antibody Anti-Cartilage Glycoprotein 39 antibody Anti-Cgp-39 antibody Anti-Gp-39 antibody Anti-Hcgp-39 antibody Anti-Ykl-40 antibody Anti-CHI3L1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHI3L1 antibody (22-383) (STJ116193)