Human SHP (Small Heterodimer Partner) Sandwich ELISA Kit (STJE0012156) STJE0012156 上海玉博生物科技有限公司

Human SHP (Small Heterodimer Partner) Sandwich ELISA Kit (STJE0012156)

简单介绍

Human SHP (Small Heterodimer Partner) Sandwich ELISA Kit (STJE0012156)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.054ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This SHP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	NR0B2
Gene ID:	8431
Uniprot ID:	NR0B2_HUMAN
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Liver. Low levels of expression were detected in heart and pancreas.
Post Translational Modifications	Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
Function	Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism. Regulates the circadian expression of cytochrome P450 (CYP) enzymes. Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14.
Protein Name	Nuclear Receptor Subfamily 0 Group B Member 2 Orphan Nuclear Receptor Shp Small Heterodimer Partner
Database Links	Reactome: R-HSA-383280
Cellular Localisation	Nucleus Cytoplasm Colocalizes With Neurod1 In The Nucleus
Alternative ELISA Names	Nuclear Receptor Subfamily 0 Group B Member 2 ELISA kit Orphan Nuclear Receptor Shp ELISA kit Small Heterodimer Partner ELISA kit NR0B2 ELISA kit SHP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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