Anti-CHMP1A antibody (STJA0007030) STJA0007030 上海玉博生物科技有限公司

Anti-CHMP1A antibody (STJA0007030)

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产品名称：Anti-CHMP1A antibody (STJA0007030)
产品型号：STJA0007030
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHMP1A antibody (STJA0007030)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Charged multivesicular body protein 1a is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHMP1A
Gene ID:	5119
Uniprot ID:	CHM1A_HUMAN
Specificity:	This antibody detects endogenous levels of CHMP1A at Human, Mouse
Immunogen:	Synthesized peptide derived from human CHMP1A

Function	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
Protein Name	Charged Multivesicular Body Protein 1a Chromatin-Modifying Protein 1a Chmp1a Vacuolar Protein Sorting-Associated Protein 46-1 Vps46-1 Hvps46-1
Database Links	Reactome: R-HSA-9610379
Cellular Localisation	Cytoplasm Endosome Membrane Peripheral Membrane Protein Nucleus Matrix The Cytoplasmic Form Is Partially Membrane-Associated And Localizes To Early Endosomes The Nuclear Form Remains Associated With The Chromosome Scaffold During Mitosis On Overexpression It Localizes To Nuclear Bodies Characterized By Nuclease-Resistant Condensed Chromatin
Alternative Antibody Names	Anti-Charged Multivesicular Body Protein 1a antibody Anti-Chromatin-Modifying Protein 1a antibody Anti-Chmp1a antibody Anti-Vacuolar Protein Sorting-Associated Protein 46-1 antibody Anti-Vps46-1 antibody Anti-Hvps46-1 antibody Anti-CHMP1A antibody Anti-CHMP1 antibody Anti-KIAA0047 antibody Anti-PCOLN3 antibody Anti-PRSM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHMP1A antibody (STJA0007030)