Anti-CHMP2A antibody (1-222) (STJ112416) STJ112416 上海玉博生物科技有限公司

Anti-CHMP2A antibody (1-222) (STJ112416)

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产品名称：Anti-CHMP2A antibody (1-222) (STJ112416)
产品型号：STJ112416
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHMP2A antibody (1-222) (STJ112416)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CHMP2A (1-222) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHMP2A
Gene ID:	27243
Uniprot ID:	CHM2A_HUMAN
Immunogen Region:	1-222
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human CHMP2A (NP_055268.1).
Immunogen Sequence:	MDLLFGRRKTPEELLRQNQR ALNRAMRELDRERQKLETQE KKIIADIKKMAKQGQMDAVR IMAKDLVRTRRYVRKFVLMR ANIQAVSLKIQTLKSNNSMA QAMKGVTKAMGTMNRQLKLP QIQKIMMEFERQAEIMDMKE EMMNDAIDDAMGDEEDEEES DAVVSQVLDELGLSLTDELS NLPSTGGSLSVAAGGKKAEA AASALADADADLEERLKNLR RD

Post Translational Modifications	ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively.
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.
Protein Name	Charged Multivesicular Body Protein 2a Chromatin-Modifying Protein 2a Chmp2a Putative Breast Adenocarcinoma Marker Bc-2 Vacuolar Protein Sorting-Associated Protein 2-1 Vps2-1 Hvps2-1
Database Links	Reactome: R-HSA-162588 Reactome: R-HSA-1632852 Reactome: R-HSA-432720 Reactome: R-HSA-5620971 Reactome: R-HSA-917729 Reactome: R-HSA-9610379 Reactome: R-HSA-9615710 Reactome: R-HSA-9668328 Reactome: R-HSA-9679504 Reactome: R-HSA-9694676
Cellular Localisation	Late Endosome Membrane Peripheral Membrane Protein Cytoplasmic Side Nucleus Envelope Localizes To The Midbody Of Dividing Cells Localized In Two Distinct Rings On Either Side Of The Fleming Body Localizes To The Reforming Nuclear Envelope On Chromatin Disks During Late Anaphase
Alternative Antibody Names	Anti-Charged Multivesicular Body Protein 2a antibody Anti-Chromatin-Modifying Protein 2a antibody Anti-Chmp2a antibody Anti-Putative Breast Adenocarcinoma Marker Bc-2 antibody Anti-Vacuolar Protein Sorting-Associated Protein 2-1 antibody Anti-Vps2-1 antibody Anti-Hvps2-1 antibody Anti-CHMP2A antibody Anti-BC2 antibody Anti-CHMP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHMP2A antibody (1-222) (STJ112416)