Anti-CHMP2B antibody (1-213) (STJ27352) STJ27352 上海玉博生物科技有限公司

Anti-CHMP2B antibody (1-213) (STJ27352)

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产品名称：Anti-CHMP2B antibody (1-213) (STJ27352)
产品型号：STJ27352
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHMP2B antibody (1-213) (STJ27352)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CHMP2B (1-213) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHMP2B
Gene ID:	25978
Uniprot ID:	CHM2B_HUMAN
Immunogen Region:	1-213
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human CHMP2B (NP_054762.2).
Immunogen Sequence:	MASLFKKKTVDDVIKEQNRE LRGTQRAIIRDRAALEKQEK QLELEIKKMAKIGNKEACKV LAKQLVHLRKQKTRTFAVSS KVTSMSTQTKVMNSQMKMAG AMSTTAKTMQAVNKKMDPQK TLQTMQNFQKENMKMEMTEE MINDTLDDIFDGSDDEEESQ DIVNQVLDEIGIEISGKMAK APSAARSLPSASTSKATISD EEIERQLKALGVD

Tissue Specificity	Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen.
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Protein Name	Charged Multivesicular Body Protein 2b Chmp2.5 Chromatin-Modifying Protein 2b Chmp2b Vacuolar Protein Sorting-Associated Protein 2-2 Vps2-2 Hvps2-2
Database Links	Reactome: R-HSA-162588 Reactome: R-HSA-1632852 Reactome: R-HSA-5620971 Reactome: R-HSA-917729 Reactome: R-HSA-9610379 Reactome: R-HSA-9615710 Reactome: R-HSA-9668328 Reactome: R-HSA-9679504 Reactome: R-HSA-9694676
Cellular Localisation	Cytoplasm Cytosol Late Endosome Membrane Peripheral Membrane Protein
Alternative Antibody Names	Anti-Charged Multivesicular Body Protein 2b antibody Anti-Chmp2.5 antibody Anti-Chromatin-Modifying Protein 2b antibody Anti-Chmp2b antibody Anti-Vacuolar Protein Sorting-Associated Protein 2-2 antibody Anti-Vps2-2 antibody Anti-Hvps2-2 antibody Anti-CHMP2B antibody Anti-CGI-84 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHMP2B antibody (1-213) (STJ27352)