Anti-CHMP3 antibody (1-222) (STJ112344) STJ112344 上海玉博生物科技有限公司

Anti-CHMP3 antibody (1-222) (STJ112344)

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产品名称：Anti-CHMP3 antibody (1-222) (STJ112344)
产品型号：STJ112344
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHMP3 antibody (1-222) (STJ112344)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-VPS24 (1-222) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHMP3
Gene ID:	100526767/51652
Uniprot ID:	CHMP3_HUMAN
Immunogen Region:	1-222
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human VPS24 (NP_057163.1).
Immunogen Sequence:	MGLFGKTQEKPPKELVNEWS LKIRKEMRVVDRQIRDIQRE EEKVKRSVKDAAKKGQKDVC IVLAKEMIRSRKAVSKLYAS KAHMNSVLMGMKNQLAVLRV AGSLQKSTEVMKAMQSLVKI PEIQATMRELSKEMMKAGII EEMLEDTFESMDDQEEMEEE AEMEIDRILFEITAGALGKA PSKVTDALPEPEPPGAMAAS EDEEEEEEALEAMQSRLATL RS

Tissue Specificity	Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
Protein Name	Charged Multivesicular Body Protein 3 Chromatin-Modifying Protein 3 Neuroendocrine Differentiation Factor Vacuolar Protein Sorting-Associated Protein 24 Hvps24
Database Links	Reactome: R-HSA-162588 Reactome: R-HSA-1632852 Reactome: R-HSA-5620971 Reactome: R-HSA-917729 Reactome: R-HSA-9610379 Reactome: R-HSA-9615710 Reactome: R-HSA-9668328 Reactome: R-HSA-9679504 Reactome: R-HSA-9694676
Cellular Localisation	Cytoplasm Cytosol Membrane Lipid-Anchor Endosome Late Endosome Membrane Localizes To The Midbody Of Dividing Cells
Alternative Antibody Names	Anti-Charged Multivesicular Body Protein 3 antibody Anti-Chromatin-Modifying Protein 3 antibody Anti-Neuroendocrine Differentiation Factor antibody Anti-Vacuolar Protein Sorting-Associated Protein 24 antibody Anti-Hvps24 antibody Anti-CHMP3 antibody Anti-CGI149 antibody Anti-NEDF antibody Anti-VPS24 antibody Anti-CGI-149 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHMP3 antibody (1-222) (STJ112344)