Anti-CHMP4B antibody (1-224) (STJ29539) STJ29539 上海玉博生物科技有限公司

Anti-CHMP4B antibody (1-224) (STJ29539)

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产品名称：Anti-CHMP4B antibody (1-224) (STJ29539)
产品型号：STJ29539
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHMP4B antibody (1-224) (STJ29539)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CHMP4B (1-224) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHMP4B
Gene ID:	128866
Uniprot ID:	CHM4B_HUMAN
Immunogen Region:	1-224
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human CHMP4B (NP_789782.1).
Immunogen Sequence:	MSVFGKLFGAGGGKAGKGGP TPQEAIQRLRDTEEMLSKKQ EFLEKKIEQELTAAKKHGTK NKRAALQALKRKKRYEKQLA QIDGTLSTIEFQREALENAN TNTEVLKNMGYAAKAMKAAH DNMDIDKVDELMQDIADQQE LAEEISTAISKPVGFGEEFD EDELMAELEELEQEELDKNL LEISGPETVPLPNVPSIALP SKPAKKKEEEDDDMKELENW AGSM

Tissue Specificity	Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.
Post Translational Modifications	ISGylated. Isgylation weakens its interaction with VPS4A.
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan. (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
Protein Name	Charged Multivesicular Body Protein 4b Chromatin-Modifying Protein 4b Chmp4b Snf7 Homolog Associated With Alix 1 Snf7-2 Hsnf7-2 Vacuolar Protein Sorting-Associated Protein 32-2 Vps32-2 Hvps32-2
Database Links	Reactome: R-HSA-162588 Reactome: R-HSA-1632852 Reactome: R-HSA-5620971 Reactome: R-HSA-917729 Reactome: R-HSA-9610379 Reactome: R-HSA-9615710 Reactome: R-HSA-9668328 Reactome: R-HSA-9679504 Reactome: R-HSA-9694676
Cellular Localisation	Cytoplasm Cytosol Late Endosome Membrane Peripheral Membrane Protein Midbody Nucleus Envelope Recruited To The Nuclear Envelope By Chmp7 During Late Anaphase Localizes Transiently To The Midbody Arms Immediately Before Abscission
Alternative Antibody Names	Anti-Charged Multivesicular Body Protein 4b antibody Anti-Chromatin-Modifying Protein 4b antibody Anti-Chmp4b antibody Anti-Snf7 Homolog Associated With Alix 1 antibody Anti-Snf7-2 antibody Anti-Hsnf7-2 antibody Anti-Vacuolar Protein Sorting-Associated Protein 32-2 antibody Anti-Vps32-2 antibody Anti-Hvps32-2 antibody Anti-CHMP4B antibody Anti-C20orf178 antibody Anti-SHAX1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHMP4B antibody (1-224) (STJ29539)