Anti-Caspase 3 antibody (Internal) (STJ70944) STJ70944-100 上海玉博生物科技有限公司

Anti-Caspase 3 antibody (Internal) (STJ70944)

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产品名称：Anti-Caspase 3 antibody (Internal) (STJ70944)
产品型号：STJ70944-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Caspase 3 antibody (Internal) (STJ70944)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IF/ICC
Reactivity:	Human/Mouse/Rat/Dog
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-Caspase 3 (Internal) is suitable for use in ELISA, Western Blot, Immunofluorescence and Immunocytochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IF-Strong expression of the protein seen in the cytoplasm of U251 cells. 10µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	CASP3
Gene ID:	836
Uniprot ID:	CASP3_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_004337.2; NP_116786.1
Specificity:	This antibody is expected to recognise both reported isoforms (NP_004337.2 and NP_116786.1).
Immunogen Sequence:	RDVSKEDHSKRS

Post Translational Modifications	Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa. S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. (Microbial infection) ADP-riboxanation by C.violaceum CopC blocks CASP3 processing, preventing CASP3 activation and ability to recognize and cleave substrates.
Function	Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis. Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface.
Protein Name	Caspase-3 Casp-3 Apopain Cysteine Protease Cpp32 Cpp-32 Protein Yama Srebp Cleavage Activity 1 Sca-1 Cleaved Into - Caspase-3 Subunit P17 - Caspase-3 Subunit P12
Database Links	Reactome: R-HSA-111459 Reactome: R-HSA-111463 Reactome: R-HSA-111464 Reactome: R-HSA-111465 Reactome: R-HSA-111469 Reactome: R-HSA-140342 Reactome: R-HSA-1474228 Reactome: R-HSA-2028269 Reactome: R-HSA-205025 Reactome: R-HSA-211736 Reactome: R-HSA-264870 Reactome: R-HSA-351906 Reactome: R-HSA-418889 Reactome: R-HSA-449836 Reactome: R-HSA-5620971
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Caspase-3 antibody Anti-Casp-3 antibody Anti-Apopain antibody Anti-Cysteine Protease Cpp32 antibody Anti-Cpp-32 antibody Anti-Protein Yama antibody Anti-Srebp Cleavage Activity 1 antibody Anti-Sca-1 Cleaved Into - Caspase-3 Subunit P17 - Caspase-3 Subunit P12 antibody Anti-CASP3 antibody Anti-CPP32 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Caspase 3 antibody (Internal) (STJ70944)