Human SKP2 (S-Phase Kinase Associated Protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0018570) STJE0018570 上海玉博生物科技有限公司

Human SKP2 (S-Phase Kinase Associated Protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0018570)

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产品名称：Human SKP2 (S-Phase Kinase Associated Protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0018570)
产品型号：STJE0018570
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SKP2 (S-Phase Kinase Associated Protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0018570)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.061ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This SKP2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	SKP2
Gene ID:	6502
Uniprot ID:	SKP2_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13. Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.
Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.
Protein Name	S-Phase Kinase-Associated Protein 2 Cyclin-A/Cdk2-Associated Protein P45 F-Box Protein Skp2 F-Box/Lrr-Repeat Protein 1 P45skp2
Database Links	Reactome: R-HSA-174178 Reactome: R-HSA-187577 Reactome: R-HSA-5689880 Reactome: R-HSA-68949 Reactome: R-HSA-69231 Reactome: R-HSA-8939902 Reactome: R-HSA-8951664 Reactome: R-HSA-9687136 Reactome: R-HSA-9708530 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Nucleus
Alternative ELISA Names	S-Phase Kinase-Associated Protein 2 ELISA kit Cyclin-A/Cdk2-Associated Protein P45 ELISA kit F-Box Protein Skp2 ELISA kit F-Box/Lrr-Repeat Protein 1 ELISA kit P45skp2 ELISA kit SKP2 ELISA kit FBXL1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SKP2 (S-Phase Kinase Associated Protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0018570)