Human SLAMF7 (Signaling Lymphocytic Activation Molecule Family, Member 7) Sandwich ELISA Kit Ready-To-Use (STJE0018571) STJE0018571 上海玉博生物科技有限公司

Human SLAMF7 (Signaling Lymphocytic Activation Molecule Family, Member 7) Sandwich ELISA Kit Ready-To-Use (STJE0018571)

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产品名称：Human SLAMF7 (Signaling Lymphocytic Activation Molecule Family, Member 7) Sandwich ELISA Kit Ready-To-Use (STJE0018571)
产品型号：STJE0018571
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SLAMF7 (Signaling Lymphocytic Activation Molecule Family, Member 7) Sandwich ELISA Kit Ready-To-Use (STJE0018571)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.053ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This SLAMF7 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	SLAMF7
Gene ID:	57823
Uniprot ID:	SLAF7_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1.
Post Translational Modifications
Function	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines. Isoform 3 does not mediate any NK cell activation.
Protein Name	Slam Family Member 7 Cd2 Subset 1 Cd2-Like Receptor-Activating Cytotoxic Cells Cracc Membrane Protein Foap-12 Novel Ly9 Protein 19a Cd Antigen Cd319
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative ELISA Names	Slam Family Member 7 ELISA kit Cd2 Subset 1 ELISA kit Cd2-Like Receptor-Activating Cytotoxic Cells ELISA kit Cracc ELISA kit Membrane Protein Foap-12 ELISA kit Novel Ly9 ELISA kit Protein 19a ELISA kit Cd Antigen Cd319 ELISA kit SLAMF7 ELISA kit CS1 ELISA kit UNQ576 ELISA kit PRO1138 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SLAMF7 (Signaling Lymphocytic Activation Molecule Family, Member 7) Sandwich ELISA Kit Ready-To-Use (STJE0018571)