Human SLC16A1 (Solute Carrier Family 16, Member 1) Sandwich ELISA Kit Ready-To-Use (STJE0018574) STJE0018574 上海玉博生物科技有限公司

Human SLC16A1 (Solute Carrier Family 16, Member 1) Sandwich ELISA Kit Ready-To-Use (STJE0018574)

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产品名称：Human SLC16A1 (Solute Carrier Family 16, Member 1) Sandwich ELISA Kit Ready-To-Use (STJE0018574)
产品型号：STJE0018574
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SLC16A1 (Solute Carrier Family 16, Member 1) Sandwich ELISA Kit Ready-To-Use (STJE0018574)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.116ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This SLC16A1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	SLC16A1
Gene ID:	6566
Uniprot ID:	MOT1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Widely expressed. Detected in heart and in blood lymphocytes and monocytes (at protein level).
Post Translational Modifications
Function	Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition.
Protein Name	Monocarboxylate Transporter 1 Mct 1 Solute Carrier Family 16 Member 1
Database Links	Reactome: R-HSA-210991 Reactome: R-HSA-433692 Reactome: R-HSA-5619070 Reactome: R-HSA-70268 Reactome: R-HSA-9749641
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Apical Cell Membrane Expression At The Cell Surface Requires The Ancillary Proteins Bsg And Emb Binds Preferentially To Bsg
Alternative ELISA Names	Monocarboxylate Transporter 1 ELISA kit Mct 1 ELISA kit Solute Carrier Family 16 Member 1 ELISA kit SLC16A1 ELISA kit MCT1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SLC16A1 (Solute Carrier Family 16, Member 1) Sandwich ELISA Kit Ready-To-Use (STJE0018574)