Human SLC39A6 (Solute Carrier Family 39, Member 6) Sandwich ELISA Kit Ready-To-Use (STJE0018598) STJE0018598 上海玉博生物科技有限公司

Human SLC39A6 (Solute Carrier Family 39, Member 6) Sandwich ELISA Kit Ready-To-Use (STJE0018598)

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产品名称：Human SLC39A6 (Solute Carrier Family 39, Member 6) Sandwich ELISA Kit Ready-To-Use (STJE0018598)
产品型号：STJE0018598
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SLC39A6 (Solute Carrier Family 39, Member 6) Sandwich ELISA Kit Ready-To-Use (STJE0018598)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.114ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This SLC39A6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	SLC39A6
Gene ID:	25800
Uniprot ID:	S39A6_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.
Post Translational Modifications	Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation.
Function	Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition.
Protein Name	Zinc Transporter Zip6 Estrogen-Regulated Protein Liv-1 Solute Carrier Family 39 Member 6 Zrt- And Irt-Like Protein 6 Zip-6
Database Links	Reactome: R-HSA-442380
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Projection Lamellipodium Membrane Membrane Raft Apical Cell Membrane Localizes To Lipid Rafts In T Cells And Is Recruited Into The Immunological Synapse In Response To Tcr Stimulation In The Choroid Plexus Is Limited To The Apical Membrane In Epithelial Cells
Alternative ELISA Names	Zinc Transporter Zip6 ELISA kit Estrogen-Regulated Protein Liv-1 ELISA kit Solute Carrier Family 39 Member 6 ELISA kit Zrt- And Irt-Like Protein 6 ELISA kit Zip-6 ELISA kit SLC39A6 ELISA kit LIV1 ELISA kit ZIP6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SLC39A6 (Solute Carrier Family 39, Member 6) Sandwich ELISA Kit Ready-To-Use (STJE0018598)