Anti-CHRNA1 antibody (105-220) (STJ27259) STJ27259 上海玉博生物科技有限公司

Anti-CHRNA1 antibody (105-220) (STJ27259)

简单介绍

Anti-CHRNA1 antibody (105-220) (STJ27259)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CHRNA1 (105-220) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHRNA1
Gene ID:	1134
Uniprot ID:	ACHA_HUMAN
Immunogen Region:	105-220
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 105-220 of human CHRNA1 (NP_000070.1).
Immunogen Sequence:	IWRPDLVLYNNADGDFAIVK FTKVLLQYTGHITWTPPAIF KSYCEIIVTHFPFDEQNCSM KLGTWTYDGSVVAINPESDQ PDLSNFMESGEWVIKESRGW KHSVTYSCCPDTPYLD

Tissue Specificity	Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
Function	Isoform 1: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Isoform 2: Non functional acetylcholine receptor alpha subunit which is not integrated into functional acetylcholine-gated cation-selective channels.
Protein Name	Acetylcholine Receptor Subunit Alpha
Database Links	Reactome: R-HSA-629594 Reactome: R-HSA-629597
Cellular Localisation	Postsynaptic Cell Membrane Multi-Pass Membrane Protein Cell Membrane
Alternative Antibody Names	Anti-Acetylcholine Receptor Subunit Alpha antibody Anti-CHRNA1 antibody Anti-ACHRA antibody Anti-CHNRA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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