Anti-CHRNA7 antibody (23-230) (STJ111098) STJ111098 上海玉博生物科技有限公司

Anti-CHRNA7 antibody (23-230) (STJ111098)

简单介绍

Anti-CHRNA7 antibody (23-230) (STJ111098)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CHRNA7 (23-230) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHRNA7
Gene ID:	1139/89832
Uniprot ID:	ACHA7_HUMAN
Immunogen Region:	23-230
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 23-230 of human CHRNA7 (NP_001177384.1).
Immunogen Sequence:	ASPPSTPPWDPGHIPGASVR PAPGPVSLQGEFQRKLYKEL VKNYNPLERPVANDSQPLTV YFSLSLLQIMDVDEKNQVLT TNIWLQMSWTDHYLQWNVSE YPGVKTVRFPDGQIWKPDIL LYNSADERFDATFHTNVLVN SSGHCQYLPPGIFKSSCYID VRWFPFDVQHCKLKFGSWSY GGWSLDLQMQEADISGYIPN GEWDLVGI

Post Translational Modifications	Glycosylations at Asn-46, Asn-90 and Asn-133 are essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to the cell membrane.
Function	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Protein Name	Neuronal Acetylcholine Receptor Subunit Alpha-7
Database Links	Reactome: R-HSA-629594
Cellular Localisation	Postsynaptic Cell Membrane Multi-Pass Membrane Protein Cell Membrane Tmem35a/Nacho Promotes Its Trafficking To The Cell Membrane Ric3 Promotes Its Trafficking To The Cell Membrane
Alternative Antibody Names	Anti-Neuronal Acetylcholine Receptor Subunit Alpha-7 antibody Anti-CHRNA7 antibody Anti-NACHRA7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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