Anti-Catenin-Alpha E/N antibody (857-906 aa) (STJ92034) STJ92034 上海玉博生物科技有限公司

Anti-Catenin-Alpha E/N antibody (857-906 aa) (STJ92034)

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产品名称：Anti-Catenin-Alpha E/N antibody (857-906 aa) (STJ92034)
产品型号：STJ92034
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Catenin-Alpha E/N antibody (857-906 aa) (STJ92034)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Catenin alpha-1 and Catenin alpha-2 (857-906 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CTNNA1 CTNNA2
Gene ID:	1495 1496
Uniprot ID:	CTNA1_HUMAN CTNA2_HUMAN
Immunogen Region:	857-906 aa
Specificity:	Catenin-Alpha E/N Polyclonal Antibody detects endogenous levels of Catenin-Alpha E/N protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Catenin-alpha1 at the amino acid range 857-906

Post Translational Modifications	Sumoylated. Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
Function	Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. May play a crucial role in cell differentiation.
Protein Name	Catenin Alpha-1 Alpha E-Catenin Cadherin-Associated Protein Renal Carcinoma Antigen Ny-Ren-13
Database Links	Reactome: R-HSA-418990 Reactome: R-HSA-5218920 Reactome: R-HSA-525793 Reactome: R-HSA-5626467
Cellular Localisation	Isoform 1: Cytoplasm Cytoskeleton Cell Junction Adherens Junction Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Found At Cell-Cell Boundaries And Probably At Cell-Matrix Boundaries Isoform 3: Cell Membrane
Alternative Antibody Names	Anti-Catenin Alpha-1 antibody Anti-Alpha E-Catenin antibody Anti-Cadherin-Associated Protein antibody Anti-Renal Carcinoma Antigen Ny-Ren-13 antibody Anti-CTNNA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Catenin-Alpha E/N antibody (857-906 aa) (STJ92034)