Anti-CBARA1 antibody (113-126) (STJ72551) STJ72551-100 上海玉博生物科技有限公司

Anti-CBARA1 antibody (113-126) (STJ72551)

简单介绍

Anti-CBARA1 antibody (113-126) (STJ72551)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IHC
Reactivity:	Human/Mouse/Rat/Dog/Pig/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-CBARA1 (113-126) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.5-2µg/ml IHC-3.75µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	MICU1
Gene ID:	10367
Uniprot ID:	MICU1_HUMAN
Immunogen Region:	113-126
Accession Number:	NP_006068.2; NP_001182447.1
Specificity:	This antibody is expected to recognize reported isoforms 1 and 2 (NP_006068.2; NP_001182447.1).
Immunogen Sequence:	EYENRIRAYSTPDK

Function	Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Protein Name	Calcium Uptake Protein 1 - Mitochondrial Atopy-Related Autoantigen Calc Ara Calc Calcium-Binding Atopy-Related Autoantigen 1 Allergen Hom S 4
Database Links	Reactome: R-HSA-8949215 Reactome: R-HSA-8949664
Cellular Localisation	Mitochondrion Inner Membrane Single-Pass Membrane Protein Mitochondrion Intermembrane Space
Alternative Antibody Names	Anti-Calcium Uptake Protein 1 - Mitochondrial antibody Anti-Atopy-Related Autoantigen Calc antibody Anti-Ara Calc antibody Anti-Calcium-Binding Atopy-Related Autoantigen 1 antibody Anti-Allergen Hom S 4 antibody Anti-MICU1 antibody Anti-CALC antibody Anti-CBARA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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