Anti-CHST14 antibody (180-280) (STJ11100478) STJ11100478 上海玉博生物科技有限公司

Anti-CHST14 antibody (180-280) (STJ11100478)

简单介绍

Anti-CHST14 antibody (180-280) (STJ11100478)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CHST14 (180-280) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHST14
Gene ID:	113189
Uniprot ID:	CHSTE_HUMAN
Immunogen Region:	180-280
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 180-280 of human CHST14 (NP_569735.1).
Immunogen Sequence:	LKMDHRSDLVFLADLRPEEI RYRLQHYFKFLFVREPLERL LSAYRNKFGEIREYQQRYGA EIVRRYRAGAGPSPAGDDVT FPEFLRYLVDEDPERMNEHW M

Tissue Specificity	Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.
Function	Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.
Protein Name	Carbohydrate Sulfotransferase 14 Dermatan 4-Sulfotransferase 1 D4st-1 Hd4st1
Database Links	Reactome: R-HSA-2022923 Reactome: R-HSA-3595174
Cellular Localisation	Golgi Apparatus Membrane Single-Pass Type Ii Membrane Protein
Alternative Antibody Names	Anti-Carbohydrate Sulfotransferase 14 antibody Anti-Dermatan 4-Sulfotransferase 1 antibody Anti-D4st-1 antibody Anti-Hd4st1 antibody Anti-CHST14 antibody Anti-D4ST1 antibody Anti-UNQ1925 antibody Anti-PRO4400 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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