Anti-CHST4 antibody (STJA0009729) STJA0009729 上海玉博生物科技有限公司

Anti-CHST4 antibody (STJA0009729)

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产品名称：Anti-CHST4 antibody (STJA0009729)
产品型号：STJA0009729
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHST4 antibody (STJA0009729)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Carbohydrate sulfotransferase 4 is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHST4
Gene ID:	10164
Uniprot ID:	CHST4_HUMAN
Specificity:	This antibody detects endogenous levels of CHST4 at Human, Mouse
Immunogen:	Synthesized peptide derived from human CHST4

Function	Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans. Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance. Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs). The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing. Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes. Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis.
Protein Name	Carbohydrate Sulfotransferase 4 Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 3 Gst-3 High Endothelial Cells N-Acetylglucosamine 6-O-Sulfotransferase Hec-Glcnac6st L-Selectin Ligand Sulfotransferase Lsst N-Acetylglucosamine 6-O-Sulfotransferase 2 Glcnac6st-2 Gn6st-2
Database Links	Reactome: R-HSA-913709
Cellular Localisation	Golgi Apparatus Membrane Single-Pass Type Ii Membrane Protein
Alternative Antibody Names	Anti-Carbohydrate Sulfotransferase 4 antibody Anti-Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 3 antibody Anti-Gst-3 antibody Anti-High Endothelial Cells N-Acetylglucosamine 6-O-Sulfotransferase antibody Anti-Hec-Glcnac6st antibody Anti-L-Selectin Ligand Sulfotransferase antibody Anti-Lsst antibody Anti-N-Acetylglucosamine 6-O-Sulfotransferase 2 antibody Anti-Glcnac6st-2 antibody Anti-Gn6st-2 antibody Anti-CHST4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHST4 antibody (STJA0009729)