Anti-CHTOP antibody (STJA0008035) STJA0008035 上海玉博生物科技有限公司

Anti-CHTOP antibody (STJA0008035)

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产品名称：Anti-CHTOP antibody (STJA0008035)
产品型号：STJA0008035
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CHTOP antibody (STJA0008035)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Chromatin target of PRMT1 protein is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHTOP
Gene ID:	26097
Uniprot ID:	CHTOP_HUMAN
Specificity:	This antibody detects endogenous levels of C1orf77 at Human
Immunogen:	Synthesized peptide derived from human C1orf77

Post Translational Modifications	Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5.
Function	Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis. Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity.
Protein Name	Chromatin Target Of Prmt1 Protein Friend Of Prmt1 Protein Small Arginine- And Glycine-Rich Protein Srag
Database Links	Reactome: R-HSA-159236 Reactome: R-HSA-72187 Reactome: R-HSA-73856
Cellular Localisation	Nucleus Nucleolus Nucleoplasm Nucleus Speckle Mostly Associated With Facultative Heterochromatin Localizes To Regions Surrounding Nuclear Speckles Known As Perispeckles In Which Trex Complex Assembly Seems To Occur
Alternative Antibody Names	Anti-Chromatin Target Of Prmt1 Protein antibody Anti-Friend Of Prmt1 Protein antibody Anti-Small Arginine- And Glycine-Rich Protein antibody Anti-Srag antibody Anti-CHTOP antibody Anti-C1orf77 antibody Anti-FOP antibody Anti-HT031 antibody Anti-PP7704 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CHTOP antibody (STJA0008035)