Anti-CIDEC antibody (189-238 aa) (STJ92292) STJ92292 上海玉博生物科技有限公司

Anti-CIDEC antibody (189-238 aa) (STJ92292)

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产品名称：Anti-CIDEC antibody (189-238 aa) (STJ92292)
产品型号：STJ92292
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CIDEC antibody (189-238 aa) (STJ92292)

产品描述

Host:	Rabbit
Applications:	IHC/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Lipid transferase CIDEC (189-238 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CIDEC
Gene ID:	63924
Uniprot ID:	CIDEC_HUMAN
Immunogen Region:	189-238 aa
Specificity:	CIDE-3 Polyclonal Antibody detects endogenous levels of CIDE-3 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human CIDEC at the amino acid range 189-238

Post Translational Modifications	Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life (about 15 minutes in 3T3-L1 cells). Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation.
Function	Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment.
Protein Name	Lipid Transferase Cidec Cell Death Activator Cide-3 Cell Death-Inducing Dffa-Like Effector Protein C Fat-Specific Protein Fsp27 Homolog
Database Links	Reactome: R-HSA-8963889 Q96AQ7-1 Reactome: R-HSA-8964572
Cellular Localisation	Lipid Droplet Endoplasmic Reticulum Nucleus Diffuses Quickly On Lipid Droplet Surface But Becomes Trapped And Clustered At Lipid Droplet Contact Sites Thereby Enabling Its Rapid Enrichment At Lipid Droplet Contact Sites
Alternative Antibody Names	Anti-Lipid Transferase Cidec antibody Anti-Cell Death Activator Cide-3 antibody Anti-Cell Death-Inducing Dffa-Like Effector Protein C antibody Anti-Fat-Specific Protein Fsp27 Homolog antibody Anti-CIDEC antibody Anti-FSP27 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CIDEC antibody (189-238 aa) (STJ92292)