Anti-CBFA2T3 antibody (593-653) (STJ116912) STJ116912 上海玉博生物科技有限公司

Anti-CBFA2T3 antibody (593-653) (STJ116912)

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产品名称：Anti-CBFA2T3 antibody (593-653) (STJ116912)
产品型号：STJ116912
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CBFA2T3 antibody (593-653) (STJ116912)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CBFA2T3 (593-653) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:500
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CBFA2T3
Gene ID:	863
Uniprot ID:	MTG16_HUMAN
Immunogen Region:	593-653
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 593-653 of human CBFA2T3 (NP_005178.4).
Immunogen Sequence:	GQSLQGPTAVVADPVPGPPE AAHSLGPSLPVGAASPSEAG SAGPSRPGSPSPPGPLDTVP R

Tissue Specificity	Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
Function	Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A.interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. Isoform 2 functions as an A-kinase-anchoring protein.
Protein Name	Protein Cbfa2t3 Mtg8-Related Protein 2 Myeloid Translocation Gene On Chromosome 16 Protein Hmtg16 Zinc Finger Mynd Domain-Containing Protein 4
Cellular Localisation	Isoform 1: Nucleus Nucleolus The Runx1-Cbfa2t3 Fusion Protein Localizes To The Nucleoplasm Isoform 2: Nucleus Nucleoplasm Golgi Apparatus Membrane
Alternative Antibody Names	Anti-Protein Cbfa2t3 antibody Anti-Mtg8-Related Protein 2 antibody Anti-Myeloid Translocation Gene On Chromosome 16 Protein antibody Anti-Hmtg16 antibody Anti-Zinc Finger Mynd Domain-Containing Protein 4 antibody Anti-CBFA2T3 antibody Anti-MTG16 antibody Anti-MTGR2 antibody Anti-ZMYND4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CBFA2T3 antibody (593-653) (STJ116912)