Anti-CBLC antibody (219-269) (STJA0006370) STJA0006370 上海玉博生物科技有限公司

Anti-CBLC antibody (219-269) (STJA0006370)

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产品名称：Anti-CBLC antibody (219-269) (STJA0006370)
产品型号：STJA0006370
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CBLC antibody (219-269) (STJA0006370)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase CBL-C (219-269) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CBLC
Gene ID:	23624
Uniprot ID:	CBLC_HUMAN
Immunogen Region:	219-269
Specificity:	This antibody detects endogenous levels of human CBLC
Immunogen:	Synthesized peptide derived from human CBLC AA range: 219-269

Post Translational Modifications	Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR. Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC.suggesting proteasomal degradation.
Function	Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction.upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation.CD2AP converts it from an inhibitor to a promoter of RET degradation.the function limits the potency of GDNF on neuronal survival.
Protein Name	E3 Ubiquitin-Protein Ligase Cbl-C Ring Finger Protein 57 Ring-Type E3 Ubiquitin Transferase Cbl-C Sh3-Binding Protein Cbl-3 Sh3-Binding Protein Cbl-C Signal Transduction Protein Cbl-C
Alternative Antibody Names	Anti-E3 Ubiquitin-Protein Ligase Cbl-C antibody Anti-Ring Finger Protein 57 antibody Anti-Ring-Type E3 Ubiquitin Transferase Cbl-C antibody Anti-Sh3-Binding Protein Cbl-3 antibody Anti-Sh3-Binding Protein Cbl-C antibody Anti-Signal Transduction Protein Cbl-C antibody Anti-CBLC antibody Anti-CBL3 antibody Anti-RNF57 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CBLC antibody (219-269) (STJA0006370)