Anti-CIITA antibody (706-755 aa) (STJ92294) STJ92294 上海玉博生物科技有限公司

Anti-CIITA antibody (706-755 aa) (STJ92294)

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产品名称：Anti-CIITA antibody (706-755 aa) (STJ92294)
产品型号：STJ92294
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CIITA antibody (706-755 aa) (STJ92294)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-MHC class II transactivator (706-755 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CIITA
Gene ID:	4261
Uniprot ID:	C2TA_HUMAN
Immunogen Region:	706-755 aa
Specificity:	CIITA Polyclonal Antibody detects endogenous levels of CIITA protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human CIITA at the amino acid range 706-755

Function	Essential for transcriptional activity of the HLA class II promoter.activation is via the proximal promoter. Does not bind DNA. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984,. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription.the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion. Isoform 3: Exhibits dominant-negative suppression of MHC class II gene expression.
Protein Name	Mhc Class Ii Transactivator Ciita
Database Links	Reactome: R-HSA-877300
Cellular Localisation	Nucleus Pml Body Recruited To Pml Body By Pml
Alternative Antibody Names	Anti-Mhc Class Ii Transactivator antibody Anti-Ciita antibody Anti-CIITA antibody Anti-MHC2TA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CIITA antibody (706-755 aa) (STJ92294)