Anti-CKAP4 antibody (130-400) (STJ110088) STJ110088 上海玉博生物科技有限公司

Anti-CKAP4 antibody (130-400) (STJ110088)

简单介绍

Anti-CKAP4 antibody (130-400) (STJ110088)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CKAP4 (130-400) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CKAP4
Gene ID:	10970
Uniprot ID:	CKAP4_HUMAN
Immunogen Region:	130-400
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 130-400 of human CKAP4 (NP_006816.2).
Immunogen Sequence:	VLEEVQQVRRSHQDFSRQRE ELGQGLQGVEQKVQSLQATF GTFESILRSSQHKQDLTEKA VKQGESEVSRISEVLQKLQN EILKDLSDGIHVVKDARERD FTSLENTVEERLTELTKSIN DNIAIFTEVQKRSQKEINDM KAKVASLEESEGNKQDLKAL KEAVKEIQTSAKSREWDMEA LRSTLQTMESDIYTEVRELV SLKQEQQAFKEAADTERLAL QALTEKLLRSEESVSRLPE

Post Translational Modifications	Reversibly palmitoylated. Palmitoylation at Cys-100 by ZDHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Palmitoylation by ZDHHC2 is also required for its function in APF-mediated antiproliferative signaling. Increased phosphorylation during mitosis prevents binding to microtubules.
Function	Mediates the anchoring of the endoplasmic reticulum to microtubules. High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.
Protein Name	Cytoskeleton-Associated Protein 4 63-Kda Cytoskeleton-Linking Membrane Protein Climp-63 P63
Database Links	Reactome: R-HSA-381426 Reactome: R-HSA-5683826 Reactome: R-HSA-6798695 Reactome: R-HSA-8957275 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Cell Membrane Cytoplasm Cytoskeleton Perinuclear Region Translocates To The Perinuclear Region Upon Apf-Stimulation
Alternative Antibody Names	Anti-Cytoskeleton-Associated Protein 4 antibody Anti-63-Kda Cytoskeleton-Linking Membrane Protein antibody Anti-Climp-63 antibody Anti-P63 antibody Anti-CKAP4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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