Anti-CLASP2 antibody (STJ190711) STJ190711 上海玉博生物科技有限公司

Anti-CLASP2 antibody (STJ190711)

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产品名称：Anti-CLASP2 antibody (STJ190711)
产品型号：STJ190711
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CLASP2 antibody (STJ190711)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CLIP-associating protein 2 is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CLASP2
Gene ID:	23122
Uniprot ID:	CLAP2_HUMAN
Specificity:	CLAP2 Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from part of the human protein

Post Translational Modifications	Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.
Function	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Protein Name	Clip-Associating Protein 2 Cytoplasmic Linker-Associated Protein 2 Protein Orbit Homolog 2 Horbit2
Database Links	Reactome: R-HSA-141444 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-428890 Reactome: R-HSA-5663220 Reactome: R-HSA-68877 Reactome: R-HSA-9648025
Cellular Localisation	Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Chromosome Centromere Kinetochore Spindle Golgi Apparatus Trans-Golgi Network Cell Membrane Cell Projection Ruffle Membrane Localizes To Microtubule Plus Ends Localizes To Centrosomes Kinetochores And The Mitotic Spindle From Prometaphase Subsequently Localizes To The Spindle Midzone From Anaphase And To The Midbody From Telophase In Migrating Cells Localizes To The Plus Ends Of Microtubules Within The Cell Body And To The Entire Microtubule Lattice Within The Lamella Localizes To The Cell Cortex And This Requires Erc1 And Phldb2 The Memo1-Rhoa-Diaph1 Signaling Pathway Controls Localization Of The Phosphorylated Form To The Cell Membrane
Alternative Antibody Names	Anti-Clip-Associating Protein 2 antibody Anti-Cytoplasmic Linker-Associated Protein 2 antibody Anti-Protein Orbit Homolog 2 antibody Anti-Horbit2 antibody Anti-CLASP2 antibody Anti-KIAA0627 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CLASP2 antibody (STJ190711)